A Scoping Review of the Use of Pioglitazone in the Treatment of Temporo-Mandibular Joint Arthritis

Thiazolidinediones (TZDs) are a group of diabetes medications currently being investigated for anti-arthritis effectiveness, one of which is pioglitazone. The purpose of this scoping review is to evaluate the potential use of pioglitazone in the treatment of temporomandibular joint (TMJ) arthritis....

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2022-12, Vol.19 (24), p.16518
Main Authors: Turosz, Natalia, Chęcińska, Kamila, Chęciński, Maciej, Kamińska, Monika, Nowak, Zuzanna, Sikora, Maciej, Chlubek, Dariusz
Format: Article
Language:English
Subjects:
Animals
Arthritis
Arthritis, Rheumatoid - drug therapy
Cartilage
Clinical trials
Diabetes
Diabetes mellitus
Disease
Drug therapy
Inflammation
Joint diseases
Joints (anatomy)
Osteoarthritis
Pioglitazone
Pioglitazone - therapeutic use
Psoriasis
Psoriatic arthritis
Review
Rheumatism
Rheumatoid arthritis
Search engines
Temporomandibular Joint
Temporomandibular Joint Disorders - drug therapy
Thiazolidinediones
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thiazolidinediones (TZDs) are a group of diabetes medications currently being investigated for anti-arthritis effectiveness, one of which is pioglitazone. The purpose of this scoping review is to evaluate the potential use of pioglitazone in the treatment of temporomandibular joint (TMJ) arthritis. The criteria of eligibility were studies with the diagnosis of arthritis and pioglitazone treatment with a change in any inflammation index as an outcome. Of the 1169 records initially identified following the selection process, two animal studies and four clinical studies were included in the review. Improvements from the baseline were observed in each treatment group for each inflammation indicator. The results of the animal studies on the temporomandibular joints and on patients with rheumatoid and psoriatic arthritis indicate that the drug in question may have potential to treat arthritis, including within the temporomandibular joint.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph192416518