Knee Osteoarthritis in Relation to the Risk Factors of the Metabolic Syndrome Components and Environment of Origin

Background: Knee osteoarthritis (KOA) is a chronic degenerative pathology that is associated with multiple risk factors such as age, sex, obesity, or metabolic syndrome (MetS). The present clinical trial aimed to investigate the influence of the environment of origin, body mass index (BMI), and MetS...

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Bibliographic Details
Published in:Journal of clinical medicine 2022-12, Vol.11 (24), p.7302
Main Authors: Tudorachi, Nicoleta Bianca, Totu, Tiberiu, Eva, Iuliana, Bărbieru, Bogdan, Totu, Eugenia Eftimie, Fifere, Adrian, Pinteală, Tudor, Sîrbu, Paul-Dan, Ardeleanu, Valeriu
Format: Article
Language:English
Subjects:
Arthritis
Disease prevention
Genotype & phenotype
High density lipoprotein
Hyperglycemia
Hypertension
Knee
Laboratories
Metabolic disorders
Obesity
Osteoarthritis
Pain
Pathology
Professional football
Regression analysis
Risk factors
Trauma
Triglycerides
Variance analysis
X-rays
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Summary:Background: Knee osteoarthritis (KOA) is a chronic degenerative pathology that is associated with multiple risk factors such as age, sex, obesity, or metabolic syndrome (MetS). The present clinical trial aimed to investigate the influence of the environment of origin, body mass index (BMI), and MetS parameters on the KOA differentiated degrees. Methods: 85 patients were admitted for the clinical study. The KOA presence was investigated using X-rays analysis. The Kellgren−Lawrence classification (KL) of the KOA severity and the MetS characteristic parameters using freshly collected blood were performed for each patient. All data collected were used for ANOVA statistic interpretation. Results: The total cholesterol and glycemia were found to be statistically significant (p < 0.028, and p < 0.03, respectively), with a high level in patients with severe KOA compared to healthy ones. Patients from rural regions are 5.18 times more prone to develop severe KOA when compared to ones from urban areas. Conclusions: The results of the statistical analysis confirmed the correlation between the incidence and severity of KOA and the influence of increased values of BMI, glycemia, triglycerides, and total cholesterol. The investigations revealed a statistically significant influence of the environment of origin on the KOA degree of the patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11247302