Factors Likely to Affect the Uptake of Genomic Approaches to Cancer Screening in Primary Care: A Scoping Review

Genomic tests are being developed for use in cancer screening. As most screening is offered in primary care settings, primary care provider and patient perceptions of such tests are likely to affect uptake. We conducted a scoping review to synthesize information on factors likely to affect patient a...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-12, Vol.12 (12), p.2044
Main Authors: Davis, Kaitlyn V, Hallman, Mie H, DiCarlo, Melissa, Wambua, Sophie M, Jaffe, Rachel L, Welsh, Allison W, Kerber, Cameron, Yang, Hushan, Chambers, Christopher V, Myers, Ronald E
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Blood tests
Boolean
Breast cancer
Cancer
Cancer screening
Colonoscopy
Colorectal cancer
Genomics
Invasiveness
Medical screening
Patients
Perceptions
Polls & surveys
Precision medicine
Primary care
Review
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Summary:Genomic tests are being developed for use in cancer screening. As most screening is offered in primary care settings, primary care provider and patient perceptions of such tests are likely to affect uptake. We conducted a scoping review to synthesize information on factors likely to affect patient and provider use of biospecimen collection and analysis for cancer screening, methods referred to as liquid biopsy or multi-cancer early detection (MCED) testing when used to detect multiple cancers. We ultimately identified 7 articles for review and analyzed them for major themes. None reported on primary care provider perspectives. Six articles focused on patient perceptions about testing for a single cancer (colorectal), and 1 reported on patient views related to testing for multiple cancers. Factors favoring this type of testing included its non-invasiveness, and the perceived safety, convenience, and effectiveness of testing. There is a dearth of information in the literature on primary care provider perceptions about liquid biopsy and MCED testing. The limited information on patient perceptions suggests that they are receptive to such tests. Research on primary care provider and patient test-related knowledge, attitudes, and behavior is needed to guide future implementation in primary care settings.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12122044