"Infiltrative" Versus "Mass-Forming" Pancreatic Cancer: A New Radiological Classification System for Pancreatic Head Ductal Carcinoma and Its Pathological Correlation

• Published in: Journal of pancreatic cancer 2022-10, Vol.8 (1), p.9-14
• Main Authors: Darwish, Muhammad B, Logarajah, Shankar, McLaren, Patrick J, Benzie, Annie L, Schmidt, Jason, Saad, Assad J, Salicru, Mauricio, Jackson, Terence, Vedantam, Shyam, Carenza, Jeffery, Sanders, Clayton, Nagatomo, Kei, Cho, Edward, Osman, Houssam, Jeyarajah, Dhiresh Rohan
• Format: Article
• Language: English
• Subjects: Bile ducts; Classification; Liver cancer; Lymphatic system; Magnetic resonance imaging; Medical prognosis; Original; Pancreatic cancer; Pancreaticoduodenectomy; Tumors
• ISSN: 2475-3246; 2475-3246
• DOI: 10.1089/pancan.2022.0003

Resectability in localized pancreatic ductal adenocarcinoma (PDAC) is deemed through radiological criteria. Despite initial evaluation classifying tumors as "resectable," they often have ill-defined borders that can result in more extensive cancer than predicted on final pathology analysis. We attempt to categorize these tumors radiologically and define them as "infiltrative" and contrast them to more well-defined or "mass-forming" tumors and assess their correlation with surgical oncological outcomes. We hypothesize that mass-forming lesions will result in fewer positive resection margins. Patients diagnosed with PDAC of the head of the pancreas and who underwent subsequent curative intent resection between 2016 and 2018 were included. A retrospective chart review of patients was conducted and computed tomography images at the time of diagnosis were reviewed by two radiologists and scored as "mass forming" or "infiltrative" using a newly developed classification system. These classifications were then correlated with margin status. Sixty-eight consecutive pancreatoduodenectomies performed for PDAC from 2016 to 2018 were identified. After screening, 54 patients were eligible for inclusion. Radiologically defined mass-forming lesions had a trend toward a lower rate of positive resection margins (35.7% vs. 50.0%;  = 0.18), specifically the bile duct margin and pancreas margin as well as an overall larger size (4.03 cm vs. 3.25 cm,  = 0.02) compared with infiltrative lesions. We propose a new radiological definition of PDAC into "mass forming" and "infiltrative," a nomenclature that resonates with other tumor sites. Infiltrative lesions trended toward a higher rate of positive resection margins. This classification may help tailor therapy for infiltrative tumors toward a neoadjuvant approach even if they appear resectable.