Colonic Delivery of Nutrients for Sustained and Prolonged Release of Gut Peptides: A Novel Strategy for Appetite Management

Obesity is one of the major global threats to human health and risk factors for cardiometabolic diseases and certain cancers. Glucagon‐like peptide‐1 (GLP‐1) plays a major role in appetite and glucose homeostasis and recently the USFDA approved GLP‐1 agonists for the treatment of obesity and type 2...

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Bibliographic Details
Published in:Molecular nutrition & food research 2022-10, Vol.66 (19), p.e2200192-n/a
Main Authors: Kamakura, Remi, Raza, Ghulam Shere, Sodum, Nalini, Lehto, Vesa‐Pekka, Kovalainen, Miia, Herzig, Karl‐Heinz
Format: Article
Language:English
Subjects:
Appetite
Colon
Colon - metabolism
delivery systems
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - prevention & control
Gastrointestinal tract
GLP‐1
Glucagon
Glucagon-Like Peptide 1 - metabolism
Glucose - metabolism
Health risks
Homeostasis
Humans
Ingestion
Metabolic disorders
Nutrients
Obesity
Obesity - metabolism
Obesity - prevention & control
Peptide YY - metabolism
Peptides
Review
Risk analysis
Risk factors
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Summary:Obesity is one of the major global threats to human health and risk factors for cardiometabolic diseases and certain cancers. Glucagon‐like peptide‐1 (GLP‐1) plays a major role in appetite and glucose homeostasis and recently the USFDA approved GLP‐1 agonists for the treatment of obesity and type 2 diabetes. GLP‐1 is secreted from enteroendocrine L‐cells in the distal part of the gastrointestinal (GI) tract in response to nutrient ingestion. Endogenously released GLP‐1 has a very short half‐life of
ISSN:1613-4125
1613-4133
1613-4133
DOI:10.1002/mnfr.202200192