Study on Sentinel Lymph Node and Its Lymphatic Drainage Pattern of Breast Cancer by Contrast‐Enhanced Ultrasound

• Published in: Journal of ultrasound in medicine 2022-11, Vol.41 (11), p.2727-2737
• Main Authors: Luo, Yunhao, Chen, Jie, Feng, Liting, Cao, Wenbin, Wu, Hao, Ma, Miao, He, Fangting, Luo, Jing, Wu, Chihua, Liu, Jinping, Chen, Qin, Luo, Jun
• Format: Article
• Language: English
• Subjects: Axilla - pathology; breast cancer; Breast Neoplasms - pathology; Contrast Media; contrast‐enhanced ultrasound; Female; Humans; Lymph Nodes - pathology; Lymphadenopathy - pathology; lymphatic drainage channel; lymphatic drainage pattern; Original; sentinel lymph node; Sentinel Lymph Node - diagnostic imaging; Sentinel Lymph Node - pathology; Sentinel Lymph Node Biopsy; Ultrasonography
• ISSN: 0278-4297; 1550-9613
• DOI: 10.1002/jum.15957

Objectives Sentinel lymph node (SLN) and its lymphatic drainage pattern (LDP) of breast cancer were studied by contrast‐enhanced ultrasound (CEUS). Methods From July 2017 to December 2019, patients with SLN localization of breast cancer in Sichuan Academy of Medical Sciences·Sichuan Provincial People's Hospital were selected. The sentinel lymph system of breast cancer was observed by CEUS before both operation and blue staining in the surgery. The location, number, and route of sentinel lymphatic channel (SLC) were recorded, along with the number, size, and the depth from skin of SLN. LDPs were summarized according to these basic characteristics of SLC and SLN. Results A total of 368 cases were included; 465 SLCs and 423 SLNs were detected. Most of the SLCs were originated from the outer upper quadrant of areola. Eleven LDPs were found, including 31 subtypes of LDPs. There were 6 cases of type A (1.63%), 15 cases of type B (4.08%), 223 cases of type C (57.88%), 38 cases of type D (10.33%), 2 cases of type E (0.54%), 3 cases of type F (0.82%), 50 cases of type G (13.59%), 30 cases of type H (8.15%), 2 cases of type I (0.54%), 6 cases of type J (1.63%), and 3 cases of type K (0.82%). Conclusions The most common LDP of breast cancer was one SLC originated from the upper quadrant of areola with one SLN. CEUS can identify the LDP before surgery to reduce the false negative rate of SLN biopsy.