Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases

Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coe...

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Bibliographic Details
Published in:Inflammopharmacology 2023-02, Vol.31 (1), p.57-75
Main Authors: Lashgari, Naser-Aldin, Roudsari, Nazanin Momeni, Zadeh, Seyed Saeed Tamehri, Momtaz, Saeideh, Abbasifard, Mitra, Reiner, Željko, Abdolghaffari, Amir Hossein, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Dermatology
Gastroenterology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Immunology
Inflammation - drug therapy
Neurodegenerative Diseases - drug therapy
Pharmacology/Toxicology
Review
Rheumatology
Sirolimus - therapeutic use
TOR Serine-Threonine Kinases
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Summary:Inflammation plays a critical role in several diseases such as cancer, gastric, heart and nervous system diseases. Data suggest that the activation of mammalian target of rapamycin (mTOR) pathway in epithelial cells leads to inflammation. Statins, the inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA), seem to be able to inhibit the mTOR. Statins are considered to have favorable effects on inflammatory diseases by reducing the complications caused by inflammation and by regulating the inflammatory process and cytokines secretion. This critical review collected data on this topic from clinical, in vivo and in vitro studies published between 1998 and June 2022 in English from databases including PubMed, Google Scholar, Scopus, and Cochrane libraries.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-022-01077-w