Heterogeneity of Hippo signalling activity in different histopathologic subtypes of renal cell carcinoma

This study aimed to reveal the prognostic role of the Hippo pathway in different histopathological subtypes of renal cell carcinoma (RCC). The TCGA‐KIRC (n = 537), TCGA‐KIRP (n = 291) and TCGA‐KICH (n = 113), which contain data about clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC),...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2023-01, Vol.27 (1), p.66-75
Main Authors: Duong, Nguyen Xuong, Le, Minh‐Khang, Kondo, Tetsuo, Mitsui, Takahiko
Format: Article
Language:English
Subjects:
Apoptosis
Carcinoma, Renal Cell - pathology
Gene expression
Hippo Signaling Pathway
hippo signalling
Humans
Kidney cancer
Kidney Neoplasms - pathology
Medical prognosis
oncogenic pathways
Original
p53 Protein
prognosis
Renal cell carcinoma
Signal transduction
TCGA
Transcription Factors - genetics
Tumor suppressor genes
Tumors
YAP1
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Summary:This study aimed to reveal the prognostic role of the Hippo pathway in different histopathological subtypes of renal cell carcinoma (RCC). The TCGA‐KIRC (n = 537), TCGA‐KIRP (n = 291) and TCGA‐KICH (n = 113), which contain data about clear cell (ccRCC), papillary (pRCC) and chromophobe RCC (chRCC), respectively, were investigated. Gene Set Variation Analysis was used to compare the activity of many pathways within a single sample. Oncogenic pathway‐related expression differed between cases of ccRCC involving low and high Hippo pathway activity. There were two subsets of ccRCC, in which the cancer exhibited lower and higher Hippo signalling activity, respectively, compared with normal tissue. In the ccRCC cohort, lower Hippo pathway activity was associated with a higher clinical stage (p 
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.17632