Nanocarrier‐hydrogel composite delivery systems for precision drug release

Hydrogels are a class of biomaterials widely implemented in medical applications due to their biocompatibility and biodegradability. Despite the many successes of hydrogel‐based delivery systems, there remain challenges to hydrogel drug delivery such as a burst release at the time of administration,...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2022-03, Vol.14 (2), p.e1756-n/a
Main Authors: Kass, Lauren E., Nguyen, Juliane
Format: Article
Language:English
Subjects:
3D printing
Antibodies
Biocompatibility
Biocompatible Materials
Biodegradability
Biodegradation
Biomaterials
Biomedical materials
Drug delivery
Drug Delivery Systems
Drug development
Drug Liberation
Fabrication
hydrogel
Hydrogels
Hydrogels - chemistry
Hydrophobicity
nanocarrier
Nanotechnology
New technology
Nucleic acids
personalized medicine
Precision medicine
Printing, Three-Dimensional
Proteins
Three dimensional printing
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Summary:Hydrogels are a class of biomaterials widely implemented in medical applications due to their biocompatibility and biodegradability. Despite the many successes of hydrogel‐based delivery systems, there remain challenges to hydrogel drug delivery such as a burst release at the time of administration, a limited ability to encapsulate certain types of drugs (i.e., hydrophobic drugs, proteins, antibodies, and nucleic acids), and poor tunability of geometry and shape for controlled drug release. This review discusses two main important advances in hydrogel fabrication for precision drug release: first, the incorporation of nanocarriers to diversify their drug loading capability, and second, the design of hydrogels using 3D printing to precisely control drug dosing and release kinetics via high‐resolution structures and geometries. We also outline ongoing challenges and discuss opportunities to further optimize drug release from hydrogels for personalized medicine. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanocarrier‐hydrogel composite materials can be engineered to improve drug delivery and may be implemented in 3D printing to create custom‐designed drug delivery systems or tissue engineering implants.
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1756