Takotsubo Cardiomyopathy in the Setting of Myxedema Coma

Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyr...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-12, Vol.14 (12), p.e32229
Main Authors: Chan, Eric K, Brown, Cameron, Bachar, Roudi, Smith, Antonio, Srivangipuram, Sudarsana
Format: Article
Language:English
Subjects:
Cardiac arrhythmia
Cardiac catheterization
Cardiology
Cardiomyopathy
Cardiovascular disease
Case reports
Catecholamines
Coma
Coronary vessels
Dyspnea
Edema
Endocrinology/Diabetes/Metabolism
Heart failure
Hypothyroidism
Internal Medicine
Intubation
Patients
Thyroid gland
Ultrasonic imaging
Vein & artery diseases
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Summary:Myxedema coma and its treatment are potent physical stressors that likely predispose patients to develop Takotsubo cardiomyopathy (TCM). We postulate a multifactorial pathophysiology for TCM that includes a mechanism involving catecholamine-induced potentiation of cardiac adrenoreceptors during thyroid hormone replacement in the setting of severe hypothyroidism. Furthermore, TCM can be difficult to anticipate when presenting as a complication of another diagnosis. In this case report, we aim to improve awareness of TCM as a consequence of extreme hypothyroid states.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.32229