Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study

The relationship between endocrine disrupting chemical (EDC) exposure and Precocious Puberty (PP) was investigated in this pilot study, involving girls with signs of PP (P) and pre-pubertal girls (C). Risk factors for PP were assessed through questionnaires, while 17β-oestradiol (E2) levels and oest...

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Bibliographic Details
Published in:International journal of environmental research and public health 2022-12, Vol.20 (1), p.14
Main Authors: Gea, Marta, Toso, Anna, Bentivegna, Giuseppe Nicolò, Buganza, Raffaele, Abrigo, Enrica, De Sanctis, Luisa, Schilirò, Tiziana
Format: Article
Language:English
Subjects:
Age
Biomarkers
Body fat
Body mass index
Breastfeeding & lactation
Children & youth
Disruption
Eating behavior
Endocrine disruptors
Endocrine Disruptors - toxicity
Estradiol
Estrone
Exposure
Female
Girls
Humans
Immunoassay
Metabolism
Nutrition research
Overweight
Parents & parenting
PCB
Pesticides
Pilot Projects
Polychlorinated biphenyls
Pregnancy
Puberty
Puberty, Precocious - chemically induced
Questionnaires
Risk analysis
Risk factors
Rural environments
Urban environments
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Summary:The relationship between endocrine disrupting chemical (EDC) exposure and Precocious Puberty (PP) was investigated in this pilot study, involving girls with signs of PP (P) and pre-pubertal girls (C). Risk factors for PP were assessed through questionnaires, while 17β-oestradiol (E2) levels and oestrogenic activity were quantified on sera. The oestrogenic activity, expressed as E2 equivalent concentration (EEQ), was applied as EDC exposure biomarker. Questionnaires showed a low EDC knowledge, a high EDC exposure, and a potential relationship between some habits at risk for EDC exposure and PP. EEQs were similar between C and P; however, they were significantly higher in girls living in an urban environment than in girls living in a rural environment, suggesting a potential higher EDC exposure in cities. The results of this pilot study highlighted the need to raise awareness on EDCs and can be considered a starting point to clarify the relationship between EDC exposure and PP.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20010014