Probiotic Bifidobacterium longum subsp. longum Protects against Cigarette Smoke-Induced Inflammation in Mice

are prominent gut commensals that produce the short-chain fatty acid (SCFA) acetate, and they are often used as probiotics. Connections between the gut and the lung, termed the gut-lung axis, are regulated by the microbiome. The gut-lung axis is increasingly implicated in cigarette smoke-induced dis...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-12, Vol.24 (1), p.252
Main Authors: Budden, Kurtis F, Gellatly, Shaan L, Vaughan, Annalicia, Amorim, Nadia, Horvat, Jay C, Hansbro, Nicole G, Wood, David L A, Hugenholtz, Philip, Dennis, Paul G, Wark, Peter A B, Hansbro, Philip M
Format: Article
Language:English
Subjects:
Acetates
Animals
Bifidobacterium
Butyrates
Cigarette Smoking
Inflammation
Mice
Probiotics - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:are prominent gut commensals that produce the short-chain fatty acid (SCFA) acetate, and they are often used as probiotics. Connections between the gut and the lung, termed the gut-lung axis, are regulated by the microbiome. The gut-lung axis is increasingly implicated in cigarette smoke-induced diseases, and cigarette smoke exposure has been associated with depletion of species. In this study, we assessed the impact of acetate-producing subsp. (WT) and a mutant strain with an impaired acetate production capacity (MUT) on cigarette smoke-induced inflammation. The mice were treated with WT or MUT subsp. and exposed to cigarette smoke for 8 weeks before assessments of lung inflammation, lung tissue gene expression and cecal SCFAs were performed. Both strains of subsp. reduced lung inflammation, inflammatory cytokine expression and adhesion factor expression and alleviated cigarette smoke-induced depletion in caecum butyrate. Thus, the probiotic administration of subsp. irrespective of its acetate-producing capacity, alleviated cigarette smoke-induced inflammation and the depletion of cecal butyrate levels.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24010252