Post-Cardiac Arrest: Mechanisms, Management, and Future Perspectives

Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to 22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest syndrome, which is characterized by the ischemia-reperfusion injury that affects the role body. Understanding p...

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Published in:Journal of clinical medicine 2022-12, Vol.12 (1), p.259
Main Authors: Lazzarin, Taline, Tonon, Carolina Rodrigues, Martins, Danilo, Fávero, Jr, Edson Luiz, Baumgratz, Thiago Dias, Pereira, Filipe Welson Leal, Pinheiro, Victor Rocha, Ballarin, Raquel Simões, Queiroz, Diego Aparecido Rios, Azevedo, Paula Schmidt, Polegato, Bertha Furlan, Okoshi, Marina Politi, Zornoff, Leonardo, Rupp de Paiva, Sergio Alberto, Minicucci, Marcos Ferreira
Format: Article
Language:English
Subjects:
Anemia
Apoptosis
Blood platelets
Cardiac arrest
Clinical medicine
Deoxyribonucleic acid
DNA
Edema
Enzymes
Gene expression
Hyperglycemia
Hyperthermia
Inflammation
Ischemia
Medical prognosis
Metabolism
Oxidative stress
Permeability
Production increases
Review
Traumatic brain injury
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Summary:Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to 22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest syndrome, which is characterized by the ischemia-reperfusion injury that affects the role body. Understanding physiopathology is mandatory to discover new treatment strategies and obtain better results. Besides improvements in cardiopulmonary resuscitation maneuvers, the great increase in survival rates observed in recent decades is due to new approaches to post-cardiac arrest care. In this review, we will discuss physiopathology, etiologies, and post-resuscitation care, emphasizing targeted temperature management, early coronary angiography, and rehabilitation.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12010259