Functional Benefit of Smoking Cessation and Triple Inhaler in Combustible Cigarette Smokers with Severe COPD: A Retrospective Study

Introduction: Chronic obstructive pulmonary disease (COPD) is the third cause of mortality and it is smoking-related. It is characterized by a non-reversible airflow limitation and a progressive worsening of the respiratory function. Objective: The aim of this study is to point out the benefit of sm...

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Published in:Journal of clinical medicine 2022-12, Vol.12 (1), p.234
Main Authors: Pezzuto, Aldo, Tonini, Giuseppe, Ciccozzi, Massimo, Crucitti, Pierfilippo, D'Ascanio, Michela, Cosci, Fiammetta, Tammaro, Antonella, Di Sotto, Antonella, Palermo, Teresa, Carico, Elisabetta, Ricci, Alberto
Format: Article
Language:English
Subjects:
Body mass index
Chronic obstructive pulmonary disease
Clinical medicine
Dyspnea
Informed consent
Inhalers
Patients
Quality of life
Smoking cessation
Spirometry
Statistical analysis
Task forces
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Summary:Introduction: Chronic obstructive pulmonary disease (COPD) is the third cause of mortality and it is smoking-related. It is characterized by a non-reversible airflow limitation and a progressive worsening of the respiratory function. Objective: The aim of this study is to point out the benefit of smoking cessation combined with a single inhaler triple therapy in terms of clinical and functional outcome in this setting. Methods: A retrospective analysis was performed in patients affected by severe COPD and at least one exacerbation a year, who underwent a smoking cessation program. All patients underwent a 6 min walking test, body plethysmography, and an exhaled test for carbon monoxide. The modified medical research council test (mMRC) test, the Fagestrom nicotine dependency test (FTND) and the COPD assessment test (CAT) questionnaire were also administered. All patients were checked at the baseline and in the six-month follow-up after the start of the treatment. Results: Smoking cessation was achieved by 51% of patients within a month and it was confirmed by eCO measure (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12010234