Renal Tissue Expression of BAFF and BAFF Receptors Is Associated with Proliferative Lupus Nephritis

Background: The B-cell activating factor (BAFF) controls the maturation and survival of B cells. An imbalance in this cytokine has been associated with systemic autoimmunity in SLE and lupus nephritis (LN). However, few investigations have evaluated the tissular expression of BAFF in LN. This study...

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Published in:Journal of clinical medicine 2022-12, Vol.12 (1), p.71
Main Authors: Marín-Rosales, Miguel, Palafox-Sánchez, Claudia Azucena, Franco-Topete, Ramón Antonio, Carrillo-Ballesteros, Francisco Josué, Cruz, Alvaro, Salazar-Camarena, Diana Celeste, Muñoz-Valle, José Francisco, Ramos-Solano, Francisco
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Classification
Clinical medicine
Ligands
Lupus
Medical prognosis
Monoclonal antibodies
Polyclonal antibodies
Statistical significance
Tumor necrosis factor-TNF
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Summary:Background: The B-cell activating factor (BAFF) controls the maturation and survival of B cells. An imbalance in this cytokine has been associated with systemic autoimmunity in SLE and lupus nephritis (LN). However, few investigations have evaluated the tissular expression of BAFF in LN. This study aimed to associate BAFF system expression at the tissular level with the proliferative LN classes. Methods: The analysis included eighteen kidney tissues, with sixteen LN (class III = 5, class IV = 6, class III/IV+V = 4, and class V = 1), and two controls. The tissular expression was evaluated with an immunochemistry assay. A Cytation5 imaging reader and ImageJ software were used to analyze the quantitative expression. A p-value < 0.05 was considered significant. Results: The expressions of BAFF, A proliferation-inducing ligand (APRIL), and their receptors were observed in glomerular, tubular, and interstitial zones, with BAFF being the most strongly expressed in the overall analysis. BAFF-Receptor (BR3), transmembrane activator and CALM interactor (TACI), and B-Cell maturation antigen (BCMA) displayed higher expressions in LN class IV in all zones analyzed (p < 0.05). Additionally, a positive correlation was found between APRIL, TACI, and BCMA at the glomerular level; BCMA and APRIL in the interstitial zone; and BR3, TACI, and BCMA in the tubule (p < 0.05). Conclusions: The expression of BAFF and BAFF receptors is mainly associated with LN class IV, emphasizing the participation of these receptors as an essential pathogenic factor in kidney involvement in SLE patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12010071