Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

This study evaluated the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds or hydroxyapatite (HA) scaffolds associated with polydioxanone (PDO) membrane (Plenum Guide) for guided bone regeneration in rats. Fifty-four rats were divided into three groups (n = 18 animals): autogenous b...

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Published in:Polymers 2022-12, Vol.15 (1), p.31
Main Authors: Pitol-Palin, Letícia, Frigério, Paula Buzo, Moura, Juliana, Pilatti, Livia, de Oliveira, Letícia Marques Jordão, Matsubara, Elaine Yoshiko, Tunchel, Samy, Shibli, Jamil Awad, Blay, Alberto, Saska, Sybele, Okamoto, Roberta
Format: Article
Language:English
Subjects:
3-D printers
3D printing
Analysis
Animals
Bioceramics
Bone regeneration
Bones
Calcium phosphates
Care and treatment
Ceramics
Defects
Hydroxyapatite
Identification and classification
Manufacturing
Membranes
Membranes (Technology)
Methods
Polyesters
Properties
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Software
Three dimensional printing
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Summary:This study evaluated the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds or hydroxyapatite (HA) scaffolds associated with polydioxanone (PDO) membrane (Plenum Guide) for guided bone regeneration in rats. Fifty-four rats were divided into three groups (n = 18 animals): autogenous bone + PDO membrane (Auto/PG); 3D-printed β-TCP + PDO membrane (TCP/PG); and 3D-printed HA + PDO membrane (HA/PG). A surgical defect in the parietal bone was made and filled with the respective scaffolds and PDO membrane. The animals were euthanized 7, 30, and 60 days after the surgical procedure for micro-CT, histomorphometric, and immunolabeling analyses. Micro-CT showed an increase in trabecular thickness and a decrease in trabecular separation, even with similar bone volume percentages between TCP/PG and HA/PG vs. Auto/PG. Histometric analysis showed increased bone formation at 30 days in the groups compared to 7 days postoperatively. Immunolabeling analysis showed an increase in proteins related to bone formation at 30 days, and both groups showed a similar immunolabeling pattern. This study concludes that 3D-printed scaffolds associated with PDO membrane (Plenum Guide) present similar results to autogenous bone for bone regeneration.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15010031