AgeAnno: a knowledgebase of single-cell annotation of aging in human

Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed biological mechanisms of aging-related genes at the single-cell level can help to understand the heterogeneous aging...

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Bibliographic Details
Published in:Nucleic acids research 2023-01, Vol.51 (D1), p.D805-D815
Main Authors: Huang, Kexin, Gong, Hoaran, Guan, Jingjing, Zhang, Lingxiao, Hu, Changbao, Zhao, Weiling, Huang, Liyu, Zhang, Wei, Kim, Pora, Zhou, Xiaobo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging - genetics
Aging - pathology
Child
Child, Preschool
Chromatin - genetics
Database Issue
Humans
Infant
Infant, Newborn
Knowledge Bases
Middle Aged
Single-Cell Analysis
Young Adult
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Summary:Aging is a complex process that accompanied by molecular and cellular alterations. The identification of tissue-/cell type-specific biomarkers of aging and elucidation of the detailed biological mechanisms of aging-related genes at the single-cell level can help to understand the heterogeneous aging process and design targeted anti-aging therapeutics. Here, we built AgeAnno (https://relab.xidian.edu.cn/AgeAnno/#/), a knowledgebase of single cell annotation of aging in human, aiming to provide comprehensive characterizations for aging-related genes across diverse tissue-cell types in human by using single-cell RNA and ATAC sequencing data (scRNA and scATAC). The current version of AgeAnno houses 1 678 610 cells from 28 healthy tissue samples with ages ranging from 0 to 110 years. We collected 5580 aging-related genes from previous resources and performed dynamic functional annotations of the cellular context. For the scRNA data, we performed analyses include differential gene expression, gene variation coefficient, cell communication network, transcription factor (TF) regulatory network, and immune cell proportionc. AgeAnno also provides differential chromatin accessibility analysis, motif/TF enrichment and footprint analysis, and co-accessibility peak analysis for scATAC data. AgeAnno will be a unique resource to systematically characterize aging-related genes across diverse tissue-cell types in human, and it could facilitate antiaging and aging-related disease research.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkac847