AmyloGraph: a comprehensive database of amyloid-amyloid interactions

Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), ob...

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Bibliographic Details
Published in:Nucleic acids research 2023-01, Vol.51 (D1), p.D352-D357
Main Authors: Burdukiewicz, Michał, Rafacz, Dominik, Barbach, Agnieszka, Hubicka, Katarzyna, Bąkała, Laura, Lassota, Anna, Stecko, Jakub, Szymańska, Natalia, Wojciechowski, Jakub W, Kozakiewicz, Dominika, Szulc, Natalia, Chilimoniuk, Jarosław, Jęśkowiak, Izabela, Gąsior-Głogowska, Marlena, Kotulska, Małgorzata
Format: Article
Language:English
Subjects:
Amyloid
Amyloidogenic Proteins - metabolism
Database Issue
Databases, Protein
Peptides
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Summary:Information about the impact of interactions between amyloid proteins on their fibrillization propensity is scattered among many experimental articles and presented in unstructured form. We manually curated information located in almost 200 publications (selected out of 562 initially considered), obtaining details of 883 experimentally studied interactions between 46 amyloid proteins or peptides. We also proposed a novel standardized terminology for the description of amyloid-amyloid interactions, which is included in our database, covering all currently known types of such a cross-talk, including inhibition of fibrillization, cross-seeding and other phenomena. The new approach allows for more specific studies on amyloids and their interactions, by providing very well-defined data. AmyloGraph, an online database presenting information on amyloid-amyloid interactions, is available at (http://AmyloGraph.com/). Its functionalities are also accessible as the R package (https://github.com/KotulskaLab/AmyloGraph). AmyloGraph is the only publicly available repository for experimentally determined amyloid-amyloid interactions.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkac882