The origins of age-related proinflammatory state

We hypothesized that the rising levels of inflammatory markers with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. Information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748...

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Bibliographic Details
Published in:Blood 2005-03, Vol.105 (6), p.2294-2299
Main Authors: Ferrucci, Luigi, Corsi, Annamaria, Lauretani, Fulvio, Bandinelli, Stefania, Bartali, Benedetta, Taub, Dennis D., Guralnik, Jack M., Longo, Dan L.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - blood
Biological and medical sciences
Blood Proteins - analysis
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
Female
Fundamental and applied biological sciences. Psychology
Humans
Inflammation
Inflammation - blood
Inflammation - mortality
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Miscellaneous. Technology
Molecular and cellular biology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Prevalence
Risk Factors
Sex Factors
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Summary:We hypothesized that the rising levels of inflammatory markers with aging is explained by cardiovascular risk factors and morbidity becoming progressively more prevalent in older persons. Information on inflammatory markers, cardiovascular risk factors, and diseases was collected in 595 men and 748 women sampled from the general population (age, 20-102 years). In both men and women, older age was associated with higher levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1ra), IL-18, C-reactive protein (CRP), and fibrinogen, while soluble IL-6 receptor (sIL-6r) increased significantly with age only in men. Adjusting for cardiovascular risk factors and morbidity, the age regression coefficients became substantially smaller in models predicting IL-6, IL-1ra, IL-18, and fibrinogen and larger in the model predicting sIL6r. Adjustment for cardiovascular morbidity substantially reduced the effect of age on CRP in men but not in women. Findings were confirmed in a subgroup of 51 men and 45 women with low risk profile and no cardiovascular morbidity. Part of the “proinflammatory state” in older persons is related to the high prevalence of cardiovascular risk factor and morbidity.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2004-07-2599