Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda-2016

After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify speci...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2023-01, Vol.108 (1), p.161-164
Main Authors: Kayiwa, John T, Mayanja, Martin N, Nakayiki, Teddy Muwawu, Senfuka, Fred, Mugga, Julius, Koehler, Jeffrey W, Mossel, Eric C, Lutwama, Julius J
Format: Article
Language:English
Subjects:
Aedes
Animals
Disease Outbreaks - prevention & control
Epidemics
Fever
Flavivirus
Humans
Mosquitoes
Phylogenetics
Phylogeny
Rift Valley Fever
Rift Valley fever virus
Short Report
Uganda - epidemiology
Viral infections
Viruses
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Summary:After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify species most likely involved in Rift Valley fever virus transmission. This information could be used to forecast risk and facilitate improvement of prevention and response tools for use in preventing or controlling future outbreaks. From these collections, two virus isolates were obtained, one each from a pool of Aedes tricholabis and Ae. gibbinsi. Next-generation sequencing identified both isolates as Wesselsbron virus, family Flaviviridae, a neglected arbovirus of economic importance. These are the first reported Wesselsbron virus isolates from Uganda since 1966.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.22-0481