Low-dose CT from myocardial perfusion SPECT/CT allows the detection of anemia in preoperative patients

To assess whether low-dose CT for attenuation correction of myocardial perfusion single-photon emission computed tomography (SPECT) allows for identification of anemic patients and grading anemia severity. Patients who underwent a preoperative blood-test and low-dose CT scan, as a part of a cardiac...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2022-12, Vol.29 (6), p.3236-3247
Main Authors: Gennari, Antonio G., Grünig, Hannes, Benz, Dominik C., Skawran, Stephan, Maurer, Alexander, Abukwaik, Ahmad M.A., Rossi, Alexia, Gebhard, Catherine, Buechel, Ronny R., Messerli, Michael
Format: Article
Language:English
Subjects:
Anemia
Anemia - diagnostic imaging
Cardiology
Emission-computed
Hematocrit
Hemoglobin
Humans
Imaging
Medicine
Medicine & Public Health
Myocardial Perfusion Imaging - methods
Nuclear Medicine
Original
Original Article
Perfusion
Quantitative analysis
Radiology
Retrospective Studies
Sensitivity and Specificity
Single-photon
Tomography
Tomography, Emission-Computed, Single-Photon - methods
Tomography, X-Ray Computed - methods
X-ray computed
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Summary:To assess whether low-dose CT for attenuation correction of myocardial perfusion single-photon emission computed tomography (SPECT) allows for identification of anemic patients and grading anemia severity. Patients who underwent a preoperative blood-test and low-dose CT scan, as a part of a cardiac SPECT exam, between 01 January 2015 and 31 December 2017 were enrolled in this retrospective study. Hemoglobin (Hb) levels and hematocrit were derived from clinical records. CT images were visually assessed (qualitative analysis) for the detection of inter-ventricular septum sign (IVSS) and aortic rim sign (ARS) and quantitative analysis were performed. The diagnostic accuracy for detecting anemia was compared using Hb values as the standard of reference. A total of 229 patients were included (110 with anemia; 57 mild; 46 moderate; 7 severe). The AUC of IVSS and ARS were 0.830 and 0.669, respectively (p
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-021-02899-x