Retinal Shape-Based Classification of Retinal Detachment and Posterior Vitreous Detachment Eyes

Introduction Retinal detachment is a sight-threatening emergency, with more than half of those affected suffering permanent visual impairment. A diagnostic test to identify eyes at risk before vision is threatened would enable exploration of prophylactic treatment. This report presents the use of ir...

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Bibliographic Details
Published in:Ophthalmology and therapy 2023-02, Vol.12 (1), p.155-165
Main Authors: Lake, Stewart R., Bottema, Murk J., Williams, Keryn A., Lange, Tyra, Reynolds, Karen J.
Format: Article
Language:English
Subjects:
Internal Medicine
Medicine
Medicine & Public Health
Ophthalmology
Original Research
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Summary:Introduction Retinal detachment is a sight-threatening emergency, with more than half of those affected suffering permanent visual impairment. A diagnostic test to identify eyes at risk before vision is threatened would enable exploration of prophylactic treatment. This report presents the use of irregularities in retinal shape, quantified from optical coherence tomography (OCT) images, as a biomarker for retinal detachment. Methods OCT images were taken from posterior and mid-peripheral retina of 264 individuals [97 after a posterior vitreous detachment (PVD), 99 after vitrectomy for retinal detachment and 68 after laser for a retinal tear]. Diagnoses were taken from history, examination and OCT. Retinal irregularity was quantified in the frequency domain, and the distribution of irregularity across the regions of the eye was explored to identify features exhibiting the greatest difference between retinal detachment and PVD eyes. Two of these features plus axial length were used to train a quadratic discriminant analysis classifier. Classifier performance was assessed by its sensitivity and specificity in identifying retinal detachment eyes and visualised with a receiver operating characteristic (ROC) curve. Results Validation set specificity was 84% (44/52 PVD eyes correctly labelled) and sensitivity 35% (23/64 retinal detachment eyes identified, p  = 0.02). Area under the ROC curve was 0.75 (95% confidence intervals 0.58–0.85). Retinal detachment eyes were significantly more irregular than PVD eyes in the superior retina (0.70 mm versus 0.49 mm, p  
ISSN:2193-8245
2193-6528
DOI:10.1007/s40123-022-00597-6