Comparison of predictive value of FRAX, trabecular bone score, and bone mineral density for vertebral fractures in systemic sclerosis: A cross-sectional study

Assessing fracture risk is important for managing patients with systemic sclerosis (SSc). Vertebral fracture (VF) is the most common fracture and is associated with future VF and non-VF. We aimed to evaluate the predictive value of FRAX, trabecular bone score (TBS), and bone mineral density (BMD) fo...

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Published in:Medicine (Baltimore) 2023-01, Vol.102 (2), p.e32580-e32580
Main Authors: Lee, Kyung-Ann, Kim, Hyun-Joo, Kim, Hyun-Sook
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Arthritis, Rheumatoid - complications
Bone Density
Cancellous Bone - diagnostic imaging
Cross-Sectional Studies
Female
Humans
Observational Study
Osteoporotic Fractures - complications
Osteoporotic Fractures - etiology
Risk Assessment
Risk Factors
Spinal Fractures - diagnostic imaging
Spinal Fractures - epidemiology
Spinal Fractures - etiology
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Summary:Assessing fracture risk is important for managing patients with systemic sclerosis (SSc). Vertebral fracture (VF) is the most common fracture and is associated with future VF and non-VF. We aimed to evaluate the predictive value of FRAX, trabecular bone score (TBS), and bone mineral density (BMD) for VFs, compared to rheumatoid arthritis (RA) patients and postmenopausal women, and to identify risk factors for VFs in SSc. In this cross-sectional study, prevalent VFs, 10-year probability of major osteoporotic fracture by FRAX (FRAX-MOF), TBS, and BMD were assessed in women with SSc (n = 69) and RA (n = 58), and postmenopausal women (n = 38). Risk factors for osteoporosis, modified Rodnan total skin score (mRSS), organ involvement, and patterns of nailfold capillaroscopy (NFC) were also evaluated. The accuracy of BMD (T-score ≤ −2.5), TBS and FRAX-MOF, with and without TBS adjustment, to detect prevalent VF was assessed by determining the area under the receiver operating characteristic (ROC) curve. Patients with SSc (14.5%) and RA (17.2%) had significantly more VFs than postmenopausal women (0%) ( P  = .031). Non-significant differences were observed in TBS and BMD of all groups. The FRAX-MOF were higher in RA (9.2%) than SSc group (6.1%) and postmenopausal women (5.5%) ( P  
ISSN:1536-5964
0025-7974
1536-5964
DOI:10.1097/MD.0000000000032580