Surgical treatment for pancreatic cystic lesions—implications from the multi-center and prospective German StuDoQ|Pancreas registry

• Published in: Langenbeck's archives of surgery 2023-01, Vol.408 (1), p.28-28, Article 28
• Main Authors: Henn, Jonas, Wyzlic, Patricia K., Esposito, Irene, Semaan, Alexander, Branchi, Vittorio, Klinger, Carsten, Buhr, Heinz J., Wellner, Ulrich F., Keck, Tobias, Lingohr, Philipp, Glowka, Tim R., Manekeller, Steffen, Kalff, Jörg C., Matthaei, Hanno
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Carcinoma, Pancreatic Ductal - pathology; Cardiac Surgery; General Surgery; Humans; Medicine; Medicine & Public Health; Neoplasms, Cystic, Mucinous, and Serous - pathology; Pancreas; Pancreatic Cyst - diagnosis; Pancreatic Cyst - pathology; Pancreatic Cyst - surgery; Pancreatic Intraductal Neoplasms - pathology; Pancreatic Neoplasms - pathology; Prospective Studies; Registries; Thoracic Surgery; Traumatic Surgery; Vascular Surgery
• ISSN: 1435-2451; 1435-2443; 1435-2451
• DOI: 10.1007/s00423-022-02740-0

Purpose The detection of pancreatic cystic lesions (PCL) causes uncertainty for physicians and patients, and international guidelines are based on low evidence. The extent and perioperative risk of resections of PCL in Germany needs comparison with these guidelines to highlight controversies and derive recommendations. Methods Clinical data of 1137 patients who underwent surgery for PCL between 2014 and 2019 were retrieved from the German StuDoQ|Pancreas registry. Relevant features for preoperative evaluation and predictive factors for adverse outcomes were statistically identified. Results Patients with intraductal papillary mucinous neoplasms (IPMN) represented the largest PCL subgroup ( N  = 689; 60.6%) while other entities (mucinous cystic neoplasms (MCN), serous cystic neoplasms (SCN), neuroendocrine tumors, pseudocysts) were less frequently resected. Symptoms of pancreatitis were associated with IPMN ( OR , 1.8; P  = 0.012) and pseudocysts ( OR , 4.78; P