Pyroptosis in bone loss

Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has been shown that osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells may be involved in bone loss linked with pyropto...

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Bibliographic Details
Published in:Apoptosis (London) 2023-04, Vol.28 (3-4), p.293-312
Main Authors: Li, Xinyi, Ji, Ling, Men, Xinrui, Chen, Xinyi, Zhi, Maohui, He, Shushu, Chen, Song
Format: Article
Language:English
Subjects:
Apoptosis
Arthritis
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bone loss
Bone marrow
Bone turnover
Cancer Research
Cell Biology
Chondrocytes
Estrogens
Fibroblasts
Humans
Immune system
Infections
Inflammasomes - metabolism
Laboratories
Ligaments
Macrophages
Metabolic Diseases
Metabolic disorders
Metabolites
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Oncology
Oral diseases
Osteoblasts
Osteoclasts
Pathogens
Production methods
Proteins
Pyroptosis
Pyroptosis - genetics
Review
Side effects
Tumor necrosis factor-TNF
Virology
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Summary:Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has been shown that osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells may be involved in bone loss linked with pyroptosis. So far, the involved mechanisms have not been fully elucidated. In this review, we introduced the related cells involved in the pyroptosis associated with bone loss and summarized the role of these cells in the bone metabolism during the process of pyroptosis. We also discuss the clinical potential of targeting mechanisms in the osteoclasts, osteoblasts, macrophages, chondrocytes, periodontal and gingival cells touched upon pyroptosis to treat bone loss from bone metabolic diseases as well as the challenges of avoiding potential side effects and producing efficient treatment methods.
ISSN:1360-8185
1573-675X
DOI:10.1007/s10495-022-01807-z