Botryoid embryonal rhabdomyosarcoma of the cervix: A case report

• Published in: International journal of surgery case reports 2023-01, Vol.102, p.107858, Article 107858
• Main Authors: Hermoza, Alejandro Delfos, de Macêdo Matsushita, Graziela, dos Santos, Marcelo Henrique, Schmidt, Ronaldo Luis, dos Reis, Ricardo, da Cunha Andrade, Carlos Eduardo Mattos
• Format: Article
• Language: English
• Subjects: Botryoid; Case Report; Cervix; Chemotherapy; Embryonal rhabdomyosarcoma; Surgery
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2022.107858

Rhabdomyosarcoma (RMS) is a malignant tumor that arises from embryonal skeletal muscle cells. It's responsible for 3 % of cancer cases among children aged from 0 to 14 and 1 % among adolescents and young adults aged from 15 to 19. Embryonal RMS (ERMS) is the most prevalent subtype of rhabdomyosarcoma in the female genital tract. Botryoid sarcomas are a polypoid variant of ERMS. Our objective is to describe the clinical, pathological features and the treatment of a patient diagnosed with RMS botryoid of the cervix. We report a case of a 19-year-old female patient diagnosed with botryoid RMS of the cervix. The histopathological evaluation of the cervix showed a polypoid tumor lined by squamous epithelium exhibiting a large hypocellular edematous area. It was classified as group II and stage 1, according to the IRSG multicenter studies. Cervical polypectomy was performed as an oncological surgical treatment and adjuvant chemotherapy consisting of Vincristine 1.5 mg/m2/day and Actinomycin D 0.045 mg/kg/day (VA) for 45 weeks. After 6 months of follow up, she had no evidence of recurrence. Cervical ERMS is a rare tumor, especially in adolescence. It's usually presents as a cervical polyp or multiple polyps. Multimodal approaches have remarkably improved the prognosis and decreased the need for radical surgery with its associated morbidity. There are a variety of treatment strategies for a rare disease such as cervical botryoid RMS. This case was approached through fertility-conserving surgery, followed by adjuvant chemotherapy and oncological clinical follow up. •Rhabdomyosarcoma is a malignant tumor that arises from embryonal skeletal muscle cells.•Botryoid sarcomas are a rare polypoid variant of embryonal rhabdomyosarcoma.•Multimodal approaches improve the prognosis and decreased the need for radical surgery.•Fertility-conserving surgeries in the early stages of the disease are allowed.