Characterisation of children and adolescents with acute lymphoblastic leukaemia who presented without peripheral blood blasts at diagnosis

Summary Of 1003 children with acute lymphoblastic leukaemia (ALL), 147 (14.7%) presented without peripheral blood blasts (PBB). While absence of PBB was not independently associated with survival outcomes when compared to those with PBB, patients without PBB had distinct genetic and clinical charact...

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Published in:British journal of haematology 2023-02, Vol.200 (3), p.338-343
Main Authors: Mangum, David Spencer, Bishop, Johnathon D., Zhou, Yinmei, Cheng, Cheng, Karol, Seth E., Rubnitz, Jeffrey E., Ribeiro, Raul C., Yang, Jun J., Mullighan, Charles G., Jeha, Sima, Pui, Ching‐Hon, Inaba, Hiroto
Format: Article
Language:English
Subjects:
acute lymphoblastic leukaemia
Acute lymphoblastic leukemia
Central nervous system
genotype
Genotypes
Hematology
Humans
hyperdiploidy
Leukocytes
paediatric
Peripheral blood
peripheral blood blasts
Phenotypes
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Prognosis
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Summary:Summary Of 1003 children with acute lymphoblastic leukaemia (ALL), 147 (14.7%) presented without peripheral blood blasts (PBB). While absence of PBB was not independently associated with survival outcomes when compared to those with PBB, patients without PBB had distinct genetic and clinical characteristics. Notably, we identified a novel genotype–phenotype relationship, in that the patients without PBB had a significantly higher incidence of hyperdiploid B‐ALL, accounting for almost half of all patients without PBB (46.9% vs. 22.7%, p 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18552