Oncotherapeutic Strategies in Early Onset Colorectal Cancer

Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 years of age diagnosed...

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Bibliographic Details
Published in:Cancers 2023-01, Vol.15 (2), p.552
Main Authors: O'Reilly, Mary, Linehan, Anna, Krstic, Aleksandar, Kolch, Walter, Sheahan, Kieran, Winter, Des C, Mc Dermott, Ray
Format: Article
Language:English
Subjects:
Age
Body mass index
Cancer
Cancer therapies
Chemotherapy
Colorectal cancer
Colorectal carcinoma
Diet
Etiology
Inflammatory bowel diseases
Intestinal microflora
Medical prognosis
Metastasis
Mortality
Mutation
Patients
Radiation therapy
Review
Risk factors
Tomography
Tumors
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Summary:Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 years of age diagnosed with colorectal cancer have an underlying genetic predisposition syndrome. The detection of cancer among the other 80% of patients poses a considerable task, as there is no family history to advocate for commencing early screening in this group. Patients with EOCRC have distinct social, spiritual, fertility, and financial needs from their older counterparts that need to be addressed. This review discusses the risk factors associated with the development of EOCRC and current best practice for the management of this disease.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15020552