Ferroptosis: A Novel Type of Cell Death in Male Reproduction

Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation of lethal lipid peroxides. Due to its potential in exploring disease progression and highly targeted therapies, it is still a widely discussed topic nowadays. In recent studies, it was found that ferroptosi...

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Bibliographic Details
Published in:Genes 2022-12, Vol.14 (1), p.43
Main Authors: Su, Yanjing, Liu, Zelan, Xie, Keyu, Ren, Yingxin, Li, Chunyun, Chen, Wei
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Busulfan
Cadmium
Cell Death
Cytoplasm
Drug development
Ferroptosis
Ferroptosis - genetics
Humans
Iron
Iron - metabolism
Kinases
Lipid Peroxidation
Lipids
Male
Male reproductive system
Mammals
Metabolism
Phospholipid Hydroperoxide Glutathione Peroxidase
Proteins
Reproductive system
Review
Risk factors
Sperm
Spermatogenesis
Therapeutic targets
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Summary:Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation of lethal lipid peroxides. Due to its potential in exploring disease progression and highly targeted therapies, it is still a widely discussed topic nowadays. In recent studies, it was found that ferroptosis was induced when testicular tissue was exposed to some high-risk factors, such as cadmium (Cd), busulfan, and smoking accompanied by a variety of reproductive damage characteristics, including changes in the specific morphology and ferroptosis-related features. In this literature-based review, we summarize the related mechanisms of ferroptosis and elaborate upon its relationship network in the male reproductive system in terms of three significant events: the abnormal iron metabolism, dysregulation of the Cyst(e)ine/GSH/GPX4 axis, and lipid peroxidation. It is meaningful to deeply explore the relationship between ferroptosis and the male reproductive system, which may provide suggestions regarding pristine therapeutic targets and novel drugs.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes14010043