The Complex Histopathological and Immunohistochemical Spectrum of Neuroendocrine Tumors-An Overview of the Latest Classifications

Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which may either take the shape of organoid cell aggregations or be composed of dispersed cells across various organs. Therefore, these tumors are heterogenous regarding the site of origin, functional status, degree of ag...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.1418
Main Authors: Gheorghișan-Gălățeanu, Ancuța-Augustina, Ilieșiu, Andreea, Lambrescu, Ioana Maria, Țăpoi, Dana Antonia
Format: Article
Language:English
Subjects:
20th century
Cancer
Cells
Classification
Humans
Neoplasms
Neuroendocrine Cells - pathology
Neuroendocrine tumors
Neuroendocrine Tumors - pathology
Organoids
Patients
Review
Small intestine
Thyroid gland
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neuroendocrine neoplasms (NENs) originate from the neuroendocrine cell system, which may either take the shape of organoid cell aggregations or be composed of dispersed cells across various organs. Therefore, these tumors are heterogenous regarding the site of origin, functional status, degree of aggressiveness, and prognosis. When treating patients with neuroendocrine tumors, one of the most significant challenges for physicians is determining the correct tumor grade and thus classifying patients into risk categories. Over the years, the classification of these tumors has changed significantly, often causing confusion due to clinical, molecular, and immunohistochemical variability. This review aims to outline the latest NENs classifications regardless of their site of origin. Thus, an overview of the key histopathological and immunohistochemical characteristics of NENs could pave the way to validate possible predictive and prognostic markers and also guide the therapeutic conduct.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24021418