Harnessing IgG Fc glycosylation for clinical benefit

The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, particularly sialylation and fucosylation, tunes cellul...

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Bibliographic Details
Published in:Current opinion in immunology 2022-08, Vol.77, p.102231-102231, Article 102231
Main Authors: Archer, Eva J, Gonzalez, Joseph C, Ghosh, Debopam, Mellins, Elizabeth D, Wang, Taia T
Format: Article
Language:English
Subjects:
Antigen-Antibody Complex - metabolism
Glycosylation
Humans
Immunoglobulin Fc Fragments
Immunoglobulin G - metabolism
Polysaccharides
Receptors, IgG
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Summary:The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, particularly sialylation and fucosylation, tunes cellular responses to immune complexes. We review the current understanding of the pathways and mechanisms underlying this biology, address FcγR in antigen presentation, and discuss aspects of the clinical understanding of Fc glycans in therapies and disease.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2022.102231