Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. We explored the effect of maternal circulating amino acids on fetal growth, proxied by birthweight, using two-sample...

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Bibliographic Details
Published in:EBioMedicine 2023-02, Vol.88, p.104441, Article 104441
Main Authors: Zhao, Jian, Stewart, Isobel D., Baird, Denis, Mason, Dan, Wright, John, Zheng, Jie, Gaunt, Tom R., Evans, David M., Freathy, Rachel M., Langenberg, Claudia, Warrington, Nicole M., Lawlor, Deborah A., Borges, Maria Carolina
Format: Article
Language:English
Subjects:
Amino Acids
Birth Weight - genetics
Birthweight
Causal effect
Female
Fetal Development
Genome-Wide Association Study
Genotype
GWAS
Humans
Mendelian randomisation
Mendelian Randomization Analysis - methods
Polymorphism, Single Nucleotide
Pregnancy
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Summary:Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. We explored the effect of maternal circulating amino acids on fetal growth, proxied by birthweight, using two-sample Mendelian randomisation (MR) and summary data from a genome-wide association study (GWAS) of serum amino acids levels (sample 1, n = 86,507) and a maternal GWAS of offspring birthweight in UK Biobank and Early Growth Genetics Consortium, adjusting for fetal genotype effects (sample 2, n = 406,063 with maternal and/or fetal genotype effect estimates). A total of 106 independent single nucleotide polymorphisms robustly associated with 19 amino acids (p 
ISSN:2352-3964
2352-3964
DOI:10.1016/j.ebiom.2023.104441