The Role of Mitochondrial Genes in Neurodegenerative Disorders

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrialmutations that disturb the mitochondrial functions and dynamics. There is a lack of evidencelinking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeableneuropathologi...

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Bibliographic Details
Published in:Current neuropharmacology 2022-01, Vol.20 (5), p.824-835
Main Authors: Kumar, Rajesh, Harilal, Seetha, Parambi, Della Grace Thomas, Kanthlal, S K, Rahman, Md Atiar, Alexiou, Athanasios, Batiha, Gaber El-Saber, Mathew, Bijo
Format: Article
Language:English
Subjects:
Amyotrophic Lateral Sclerosis
DNA, Mitochondrial - genetics
Genes, Mitochondrial
Humans
Mitochondrial Diseases
Mutation
Neurodegenerative Diseases - genetics
Neurology
Parkinson Disease - genetics
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Summary:Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrialmutations that disturb the mitochondrial functions and dynamics. There is a lack of evidencelinking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeableneuropathological lesions in postmortem samples. This review describes various gene mutationsin Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis,and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrialdysfunctions due to either mtDNA mutation or deletion, the mechanism of which remainsunclear in depth.
ISSN:1570-159X
1875-6190
DOI:10.2174/1570159X19666210908163839