Time-Series Change of Serum Soluble T-Cadherin Concentrations and Its Association with Creatine Kinase-MB Levels in ST-Segment Elevation Myocardial Infarction

• Published in: Journal of Atherosclerosis and Thrombosis 2022/12/01, Vol.29(12), pp.1823-1834
• Main Authors: Iioka, Masahito, Fukuda, Shiro, Maeda, Norikazu, Natsukawa, Tomoaki, Kita, Shunbun, Fujishima, Yuya, Sawano, Hirotaka, Nishizawa, Hitoshi, Shimomura, Iichiro
• Format: Article
• Language: English
• Subjects: Adiponectin; Cadherins - blood; Creatine Kinase, MB Form - blood; Humans; Original; Percutaneous Coronary Intervention; Soluble T-cadherin; ST Elevation Myocardial Infarction - diagnosis; STEMI; Treatment Outcome
• ISSN: 1340-3478; 1880-3873
• DOI: 10.5551/jat.63305

Aims: T-cadherin (T-cad) is a specific binding partner of adiponectin (APN), adipocyte-specific secretory protein. APN exhibits organ protection via the T-cad-dependent accumulation onto several tissues such as the aorta, heart, and muscle. Recently, for the first time, we showed that three forms (130, 100, and 30 kDa) of soluble T-cad existed in human serum and correlated with several clinical parameters in patients with type 2 diabetes. Nevertheless, the significance of soluble T-cad has not been elucidated in the acute stage of cardiovascular diseases. We herein examined soluble T-cad concentrations and investigated their clinical significance in patients with emergency hospital admission due to ST-segment elevation myocardial infarction (STEMI).Methods: This observational study enrolled 47 patients with STEMI who were treated via primary percutaneous coronary intervention (PCI). Soluble T-cad and APN concentrations were measured by using an enzyme-linked immunosorbent assay. This study is registered with the University Hospital Medical Information Network (Number: UMIN 000014418).Results: Serum concentrations of soluble 130 and 100 kDa T-cad rapidly and significantly decreased after hospitalization and reached the bottom at 72 h after admission (p＜0.001 and p＜0.001, respectively). The patients with high soluble T-cad and low APN concentrations on admission showed a significantly higher area under the curve of serum creatine kinase-MB (p＜0.01).Conclusion: Serum soluble T-cad concentration changed dramatically in patients with STEMI, and the high T-cad and low APN concentrations on admission were associated with the myocardial infarction size. Further study is needed to investigate the usefulness of categorizing patients with STEMI by serum T-cad and APN for the prediction of severe prognoses.