Biomarkers of mitochondrial dysfunction and inflammaging in older adults and blood pressure variability

Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as “inflammaging” and the hallmark “mitochondrial dysfunction” due to age-related stress. We aimed to...

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Bibliographic Details
Published in:GeroScience 2023-04, Vol.45 (2), p.797-809
Main Authors: Bencivenga, Leonardo, Strumia, Mathilde, Rolland, Yves, Martinez, Laurent, Cestac, Philippe, Guyonnet, Sophie, Andrieu, Sandrine, Parini, Angelo, Lucas, Alexandre, Vellas, Bruno, De Souto Barreto, Philipe, Rouch, Laure
Format: Article
Language:English
Subjects:
Aged
Aging
Biomarkers
Biomedical and Life Sciences
Blood pressure
Blood Pressure - physiology
Cell Biology
Female
Geriatrics/Gerontology
Growth Differentiation Factor 15
Humans
Inflammation
Interleukin 6
Life Sciences
Mitochondria
Molecular Medicine
Older people
Original
Original Article
Plasma levels
Population studies
Tumor necrosis factor receptor 1
Tumor necrosis factor receptors
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Summary:Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as “inflammaging” and the hallmark “mitochondrial dysfunction” due to age-related stress. We aimed to determine whether plasma levels of the pleiotropic stress-related mitokine growth/differentiation factor 15 (GDF-15) and two inflammatory biomarkers, interleukin 6 (IL-6) and tumor necrosis factor receptor 1 (TNFR-1), are associated with visit-to-visit BPV in a population of community-dwelling older adults. The study population consisted of 1096 community-dwelling participants [median age 75 (72–78) years; 699 females, 63.7%] aged ≥ 70 years from the MAPT study. Plasma blood sample was collected 12 months after enrolment and BP was assessed up to seven times over a 4-year period. Systolic (SBPV) and diastolic BPV (DBPV) were determined through several indicators taking into account BP change over time, the order of measurements and formulas independent of mean BP levels. Higher values of GDF-15 were significantly associated with increased SBPV (all indicators) after adjustment for relevant covariates [adjusted 1-SD increase in GDF-15: β (SE) = 0.07 (0.04), p  
ISSN:2509-2715
2509-2723
DOI:10.1007/s11357-022-00697-y