Glucokinase maturity-onset diabetes of the young as a mimicker of stress hyperglycemia: a case report

Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from...

Full description

Saved in:
Bibliographic Details
Published in:Clinical Pediatric Endocrinology 2023, Vol.32(1), pp.72-75
Main Authors: Nakasato, Yoshitaka, Terashita, Shintaro, Kusabiraki, Shohei, Horie, Sadashi, Wada, Takuya, Nakabayashi, Motokazu, Nakamura, Megumi, Yorifuji, Tohru
Format: Article
Language:English
Subjects:
Case Report
glucokinase
maturity-onset diabetes of the young
stress hyperglycemia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Febrile seizures are frequently accompanied by stress-induced hyperglycemia. Herein, we report the case of a 1.5-yr-old girl with hyperglycemia during febrile seizures who was subsequently diagnosed with glucokinase (GCK) maturity-onset diabetes of the young (MODY), considering its distinction from stress hyperglycemia. Following the development of febrile seizures owing to adenovirus infection, the patient presented a casual blood glucose level was 185 mg/dL. She had a multigenerational family history of diabetes and a hemoglobin A1c (HbA1c) level of 6.4%. Owing to the persistent glucose intolerance until the age of 5 years, genetic testing was performed, which revealed a heterozygous mutation in GCK, and the patient was diagnosed with GCK-MODY. Precise diagnosis of GCK-MODY individuals is important to avoid administering unnecessary antidiabetic medications. Even during hyperglycemia under stress, multigenerational diabetes and mildly elevated HbA1c levels can suggest GCK-MODY.
ISSN:0918-5739
1347-7358
DOI:10.1297/cpe.2022-0024