Gold nanoparticles capped with L-glycine, L-cystine, and L-tyrosine: toxicity profiling and antioxidant potential

Biomolecules-based surface modifications of nanomaterials may yield effective and biocompatible nanoconjugates. This study was designed to evaluate gold nanoconjugates (AuNCs) for their altered antioxidant potential. Gold nanoparticles (AuNPs) and their conjugates gave SPR peaks in the ranges of 512...

Full description

Saved in:
Bibliographic Details
Published in:Journal of materials science 2023-02, Vol.58 (6), p.2814-2837
Main Authors: Ditta, Sarwar Allah, Yaqub, Atif, Tanvir, Fouzia, Rashid, Muhammad, Ullah, Rehan, Zubair, Muhammad, Ali, Shaista, Anjum, Khalid Mahmood
Format: Article
Language:English
Subjects:
Amino acids
antioxidant activity
Antioxidants
Biocompatibility
Biomedical engineering
Biomedical materials
Biomolecules
Cadmium
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Conjugates
Crystallography and Scattering Methods
cysteine
Glycine
Gold
Hydrogen peroxide
Life sciences
Ligands
liver
Materials for Life Sciences
Materials Science
nanogold
Nanomaterials
Nanoparticles
Oxidative stress
Phenols
Polymer Sciences
Proteins
Scavenging
Sensors
Signal transduction
Silver
Solid Mechanics
Toxicity
Tyrosine
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biomolecules-based surface modifications of nanomaterials may yield effective and biocompatible nanoconjugates. This study was designed to evaluate gold nanoconjugates (AuNCs) for their altered antioxidant potential. Gold nanoparticles (AuNPs) and their conjugates gave SPR peaks in the ranges of 512–525 nm, with red or blueshift for different conjugates. Cys-AuNCs demonstrated enhanced ( p   0.05) displayed reduced DPPH activity. Gly-AuNCs and Tyr-AuNCs displayed enhanced ferric-reducing power and hydrogen peroxide scavenging activity, respectively. Cadmium-intoxicated mice were exposed to gold nanomaterials, and the level of various endogenous parameters, i.e., CAT, GST, SOD, GSH, and MTs, was evaluated. GSH and MTs in liver tissues of the cadmium-exposed group (G2) were elevated ( p  
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-023-08209-9