Comparison of integrin αvβ3 expression with 68Ga-NODAGA-RGD PET/CT and glucose metabolism with 18F-FDG PET/CT in esophageal or gastroesophageal junction cancers

Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68 Ga-NODAGA-RGD PET/CT with that of 18 F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination. Methods Ten 68 Ga-NODAGA-...

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Bibliographic Details
Published in:European journal of hybrid imaging 2023-02, Vol.7 (1), p.3-3, Article 3
Main Authors: Dietz, Matthieu, Dunet, Vincent, Mantziari, Styliani, Pomoni, Anastasia, Dias Correia, Ricardo, Testart Dardel, Nathalie, Boughdad, Sarah, Nicod Lalonde, Marie, Treglia, Giorgio, Schafer, Markus, Schaefer, Niklaus, Prior, John O.
Format: Article
Language:English
Subjects:
Adrenal glands
Cancer
Computed tomography
Correlation analysis
Esophageal cancer
Esophagus
Fluorine isotopes
Glucose metabolism
Imaging
Lesions
Lymph nodes
Lymphatic system
Malignancy
Medicine
Medicine & Public Health
Metastases
NCT
NCT02666547
Nuclear Medicine
Original
Original Article
Positron emission
Positron emission tomography
Radiology
Tumors
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Summary:Background The primary aims of this study were to compare in patients with esophageal or esophagogastric junction cancers the potential of 68 Ga-NODAGA-RGD PET/CT with that of 18 F-FDG PET/CT regarding tumoral uptake and distribution, as well as histopathologic examination. Methods Ten 68 Ga-NODAGA-RGD and ten 18 F-FDG PET/CT were performed in nine prospectively included participants (1 woman; aged 58 ± 8.4 y, range 40–69 y). Maximum SUV (SUV max ) and metabolic tumor volumes (MTV) were calculated. The Mann–Whitney U test and Spearman correlation analysis ( ρ ) were used. Results 68 Ga-NODAGA-RGD PET/CT detected positive uptake in 10 primary sites (8 for primary tumors and 2 for local relapse suspicion), 6 lymph nodes and 3 skeletal sites. 18 F-FDG PET/CT detected positive uptake in the same sites but also in 16 additional lymph nodes and 1 adrenal gland. On a lesion-based analysis, SUV max of 18 F-FDG was significantly higher than those of 68 Ga-NODAGA-RGD (4.9 [3.7–11.3] vs. 3.2 [2.6–4.2] g/mL, p  = 0.014). Only one participant showed a higher SUV max in an osseous metastasis with 68 Ga-NODAGA-RGD as compared to 18 F-FDG (6.6 vs. 3.9 g/mL). Correlation analysis showed positive correlation between 18 F-FDG and 68 Ga-NODAGA-RGD PET parameters ( ρ  = 0.56, p  = 0.012 for SUV max , ρ  = 0.78, p  
ISSN:2510-3636
2510-3636
DOI:10.1186/s41824-023-00162-9