PHGDH and cancer: new job for an old enzyme

How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non‐canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progress...

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Bibliographic Details
Published in:The EMBO journal 2023-02, Vol.42 (3), p.e113068-n/a
Main Author: Kuzuoglu‐Ozturk, Duygu
Format: Article
Language:English
Subjects:
Cell Line, Tumor
EMBO03
EMBO21
Energy metabolism
Humans
Life Sciences
Liver cancer
Mitochondria
Neoplasms - genetics
News & Views
Phosphoglycerate dehydrogenase
Phosphoglycerate Dehydrogenase - genetics
Phosphoglycerate Dehydrogenase - metabolism
Serine
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Summary:How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non‐canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer. Graphical Abstract Recent work reveals a non‐canonical function of the metabolic enzyme phosphoglycerate dehydrogenase as a regulator of mitochondrial translation and tumor progression in liver cancer.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2022113068