Simultaneous relaxometry and morphometry of human brain structures with 3D magnetic resonance fingerprinting: a multicenter, multiplatform, multifield-strength study

Relaxation times and morphological information are fundamental magnetic resonance imaging-derived metrics of the human brain that reflect the status of the underlying tissue. Magnetic resonance fingerprinting (MRF) enables simultaneous acquisition of T1 and T2 maps inherently aligned to the anatomy,...

Full description

Saved in:
Bibliographic Details
Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-01, Vol.33 (3), p.729-739
Main Authors: Fujita, Shohei, Cencini, Matteo, Buonincontri, Guido, Takei, Naoyuki, Schulte, Rolf F, Fukunaga, Issei, Uchida, Wataru, Hagiwara, Akifumi, Kamagata, Koji, Hagiwara, Yasuhiro, Matsuyama, Yutaka, Abe, Osamu, Tosetti, Michela, Aoki, Shigeki
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy
Original
Reproducibility of Results
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Relaxation times and morphological information are fundamental magnetic resonance imaging-derived metrics of the human brain that reflect the status of the underlying tissue. Magnetic resonance fingerprinting (MRF) enables simultaneous acquisition of T1 and T2 maps inherently aligned to the anatomy, allowing whole-brain relaxometry and morphometry in a single scan. In this study, we revealed the feasibility of 3D MRF for simultaneous brain structure-wise morphometry and relaxometry. Comprehensive test-retest scan analyses using five 1.5-T and three 3.0-T systems from a single vendor including different scanner types across 3 institutions demonstrated that 3D MRF-derived morphological information and relaxation times are highly repeatable at both 1.5 T and 3.0 T. Regional cortical thickness and subcortical volume values showed high agreement and low bias across different field strengths. The ability to acquire a set of regional T1, T2, thickness, and volume measurements of neuroanatomical structures with high repeatability and reproducibility facilitates the ability of longitudinal multicenter imaging studies to quantitatively monitor changes associated with underlying pathologies, disease progression, and treatments.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhac096