Denileukin diftitox-induced systemic capillary leak syndrome with acute kidney injury

Systemic capillary leak syndrome is a rare and life-threatening disorder, characterized by recurrent episodes of unexplained hypotension, hemoconcentration, and hypoalbuminemia. This condition is caused by leakage of plasma and proteins into the extravascular space and can be classified as either id...

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Bibliographic Details
Published in:CEN case reports 2023-02, Vol.12 (1), p.63-67
Main Authors: Horino, Taro, Okada, Daiki, Inotani, Satoshi, Nakajima, Hideki, Komori, Masahiro, Terada, Yoshio
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - complications
Capillary Leak Syndrome - chemically induced
Capillary Leak Syndrome - diagnosis
Capillary Leak Syndrome - drug therapy
Case Report
Humans
Interleukin-2 - adverse effects
Medicine
Medicine & Public Health
Nephrology
Skin Neoplasms - complications
Skin Neoplasms - drug therapy
Skin Neoplasms - pathology
Urology
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Description
Summary:Systemic capillary leak syndrome is a rare and life-threatening disorder, characterized by recurrent episodes of unexplained hypotension, hemoconcentration, and hypoalbuminemia. This condition is caused by leakage of plasma and proteins into the extravascular space and can be classified as either idiopathic or secondary. Secondary systemic capillary leak syndrome can result from cancer, infections, medications, or surgery. Systemic capillary leak syndrome frequently develops as a side effect of denileukin diftitox treatment of refractory cutaneous T-cell lymphoma. However, the pathophysiology of this disease is not well understood. Herein, we report a case of denileukin diftitox-induced systemic capillary leak syndrome.
ISSN:2192-4449
2192-4449
DOI:10.1007/s13730-022-00720-3