Real-World Clinical Outcomes Based on Body Mass Index and Annualized Weight Change in Patients with Idiopathic Pulmonary Fibrosis

Introduction Identification of clinical characteristics associated with prognosis for idiopathic pulmonary fibrosis (IPF) may help to guide management decisions. This analysis utilized data from the Pulmonary Fibrosis Foundation Patient Registry to examine the relationships between clinical outcomes...

Full description

Saved in:
Bibliographic Details
Published in:Advances in therapy 2023-02, Vol.40 (2), p.691-704
Main Authors: Lee, Joyce S., Martin-Schwarze, Adam, Freiheit, Elizabeth, Trzaskoma, Ben, Burg, Cindy
Format: Article
Language:English
Subjects:
Body Mass Index
Body Weight
Brief Report
Cardiology
Endocrinology
Humans
Idiopathic Pulmonary Fibrosis - complications
Internal Medicine
Medicine
Medicine & Public Health
NCT
NCT02758808
Oncology
Pharmacology/Toxicology
Rheumatology
Vital Capacity
Weight Loss
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Identification of clinical characteristics associated with prognosis for idiopathic pulmonary fibrosis (IPF) may help to guide management decisions. This analysis utilized data from the Pulmonary Fibrosis Foundation Patient Registry to examine the relationships between clinical outcomes and both body mass index (BMI) at study enrollment (hereafter referred to as baseline BMI) and annualized percent change in body weight in patients with IPF in a real-world setting. Methods The following outcomes over 24 months were stratified by baseline BMI and annualized percent change in body weight: all-cause mortality; annualized change in percent predicted forced vital capacity (%FVC), percent predicted diffusing capacity for carbon monoxide, and 6-min walk distance; all-cause and respiratory-related hospitalizations; and acute exacerbations. Results Overall, 600 patients with IPF were included (baseline BMI: 
ISSN:0741-238X
1865-8652
DOI:10.1007/s12325-022-02382-0