Pancreatic cancer, stroma, and exosomes

In the pathogenesis of pancreatic adenocarcinoma, tumor stroma plays a key role in both aggressiveness, immune evasion, resistance to chemotherapy, and the ability to metastasize. Among the elements that characterize the behavior of the stroma, extracellular vesicles and, in particular, exosomes pla...

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Bibliographic Details
Published in:Journal of physiology and biochemistry 2023-02, Vol.79 (1), p.205-211
Main Author: Closa, Daniel
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - metabolism
Animal Physiology
Biomedical and Life Sciences
Biomedicine
Cancer
Chemotherapy
Development and progression
DNA binding proteins
Drug development
Drug resistance
Exosomes
Exosomes - metabolism
Extracellular matrix
Fibroblasts
Human Physiology
Humans
Immunosuppressive agents
Leukocyte migration
Macrophages
Mesenchyme
Metastases
MicroRNA
MicroRNAs - metabolism
miRNA
Original
Original Article
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - metabolism
Pathogenesis
Phenotypes
Stroma
Therapeutic targets
Transcription factors
Tumor cells
Tumors
Vesicles
Citations: Items that this one cites
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Description
Summary:In the pathogenesis of pancreatic adenocarcinoma, tumor stroma plays a key role in both aggressiveness, immune evasion, resistance to chemotherapy, and the ability to metastasize. Among the elements that characterize the behavior of the stroma, extracellular vesicles and, in particular, exosomes play an important role. These extracellular vesicles carry a wide range of bioactive molecules, from transcription factors to microRNAs, which can substantially alter the phenotype of the cellular components of the stroma. Exosomes are involved in the exchange of signals between tumor cells, tumor-associated macrophages, cancer-associated fibroblasts, and also with the healthy cells surrounding the tumor. They can transfer resistance to chemotherapeutic drugs, promote the epithelial-mesenchymal transition, modify the phenotype of macrophages, or induce the expression of molecules that alter the extracellular matrix to facilitate migration and metastasis. On the other hand, all these characteristics make these vesicles first-rate therapeutic targets, as controlling their functionality could greatly enhance the effectiveness of treatments that, today, are still far from be satisfactory.
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-022-00898-1