Thrombosis and thrombocytopenia after HPV vaccination

Background Vaccine‐induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines. Objective We report findings in a 25‐year‐old woman who presented with thrombocytopenia, venous thrombosis...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2022-03, Vol.20 (3), p.700-704
Main Authors: Johansen, Silje, Lægreid, Ingvild Jenssen, Ernstsen, Siw Leiknes, Azrakhsh, Nessar Ahmad, Kittang, Astrid Olsnes, Lindås, Roald, Gjertsen, Bjørn Tore, Vetti, Nils, Mørtberg, Trude Victoria, Sørvoll, Ingvild Hausberg, Holme, Pål André, Ahlen, Maria Therese, Reikvam, Håkon
Format: Article
Language:English
Subjects:
Adult
antibodies
Brief Report
Case reports
Coronaviruses
COVID-19
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Female
hematology
Human papillomavirus
Humans
Immunization
Papillomavirus Infections
Platelet factor 4
Platelets
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Thrombocytopenia
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnosis
Thrombosis
Thrombosis - etiology
Vaccination - adverse effects
Vaccines
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Summary:Background Vaccine‐induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines. Objective We report findings in a 25‐year‐old woman who presented with thrombocytopenia, venous thrombosis, elevated D‐dimer levels, and high levels of platelet‐activating antibodies to platelet factor 4‐polyanion complexes 10 days after Gardasil 9 vaccination for human papillomavirus (HPV). The patient exhibited clinical and laboratory features in line with the recently defined VITT syndrome, described after adenoviral vector vaccination to prevent coronavirus disease 2019. Conclusion We report a case of VITT following HPV vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector‐based SARS‐CoV‐2 vaccines.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.15604