Clinical Correlation of Adenoviral Load in the Respiratory Tract Measured by Digital PCR in Immunocompromised Children

Abstract Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that hi...

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Bibliographic Details
Published in:Open forum infectious diseases 2023-02, Vol.10 (2), p.ofad030-ofad030
Main Authors: Hijano, Diego R, Ferrolino, Jose A, Hidinger, Jennifer, Brazelton, Jessica N, Gu, Zhengming, Suganda, Sri, Glasgow, Heather L, Allison, Kim J, Peterson, Megan, Dallas, Ronald H, Maron, Gabriela, Hayden, Randall T
Format: Article
Language:English
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Brief Report
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Summary:Abstract Immunocompromised patients can have life-threatening adenoviral infection. Viral load in blood and stool is commonly used to guide antiviral therapy. We developed and evaluated a digital polymerase chain reaction assay to quantify human adenovirus in the respiratory tract and showed that higher peak load correlates with disseminated infection, mechanical ventilation, and death.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad030