Efficacy of a fine fiber film applied with a water‐based lotion to improve dry skin

Background Dry skin can trigger eczema that affects >10% of the US population. Dressing films have been developed to improve diseased skin, but there is limited knowledge about their effects, especially for dry skin‐related symptoms. We developed an electrospinning method that creates a coating f...

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Published in:Skin research and technology 2022-05, Vol.28 (3), p.465-471
Main Authors: Gabe, Yu, Uchiyama, Masayuki, Sasaoka, Shun, Amari, Naomi, Imai, Asuka, Hachiya, Akira, Kiyomine, Akira
Format: Article
Language:English
Subjects:
conductance
direct‐electrospinning (D‐ES)
Double-Blind Method
dry skin
Eczema
Emollients - pharmacology
Female
fine fiber (FF)
Humans
Hydration
Membranes
Moisture effects
Original
Permeability
Petrolatum
Pilot Projects
Roughness
Semipermeable membranes
Skin
Skin Cream
Skin diseases
Skin Diseases - drug therapy
Treatment Outcome
Water
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Summary:Background Dry skin can trigger eczema that affects >10% of the US population. Dressing films have been developed to improve diseased skin, but there is limited knowledge about their effects, especially for dry skin‐related symptoms. We developed an electrospinning method that creates a coating film, called a fine fiber (FF) film, characterized by the production of a transparent, thin, flexible, and adherent membrane on the skin surface. Objective The aim of this pilot study was to examine the effects of the FF film on dry skin. Methods Three treatments (lotion only, lotion with the FF film, and lotion with an alternative film) were designed to treat subjects with rough skin on their lower legs. Twenty‐four females were enrolled and used either a water‐based lotion U or a petrolatum‐based lotion P and the FF film for 2 weeks followed by a regression phase for 1 week. Skin hydration and roughness scores were assessed as were the subjects’ perceptions of the effects. Results When the FF film was applied with lotion U, skin hydration was significantly improved even after 1 week, accompanied by a significant improvement of skin roughness and an increase in skin hydration by the end of the regression phase. An evaluation of moisture permeability suggested that the FF film, especially with lotion U, performed as a semipermeable membrane with optimal moisture healing effects on dry skin. Conclusion The FF film together with a water‐based lotion is a promising treatment to quickly improve dry skin conditions.
ISSN:0909-752X
1600-0846
DOI:10.1111/srt.13149