Monitoring Gut Epithelium Serotonin and Melatonin Overflow Provides Spatial Mapping of Inflammation

Electrochemical arrays were used to measure the overflow of serotonin (5‐HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical‐induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function. We show that 5‐HT overflow is...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2023-01, Vol.24 (2), p.e202200334-n/a
Main Authors: Perez, Fernando, Kotecha, Nikki, Lavoie, Brigitte, Mawe, Gary M., Patel, Bhavik Anil
Format: Article
Language:English
Subjects:
Animals
Colon
EC cells
Electrochemistry
electrode arrays
Epithelium
Gastrointestinal diseases
Inflammation
Inflammatory bowel diseases
Intestinal Mucosa
Melatonin
Mice
Overflow
Serotonin
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Summary:Electrochemical arrays were used to measure the overflow of serotonin (5‐HT) and melatonin (MEL) from the entire colon of healthy mice and mice with chemical‐induced inflammatory bowel disease (IBD), to understand the interplay between inflammation and colonic function. We show that 5‐HT overflow is increased, whilst MEL levels are reduced, in inflamed tissues. The levels of MEL are increased at the interface between healthy and inflamed regions within the colon and may limit the spread of inflammation. Understanding the interplay between inflammation and mucosal epithelial signalling can provide key insight into colonic function and aid the development of effective therapeutic strategies to treat gastrointestinal diseases. Serotonin and melatonin play critical roles in regulating gut motility, but also have a key influence on the inflammatory status of the gut. The overflow of serotonin and melatonin provided spatial mapping of inflamed regions within the colon. This finding provides new insight into the tracking and therapeutic management of inflammatory bowel disorders.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202200334