Homophila: human disease gene cognates in Drosophila

Although many human genes have been associated with genetic diseases, knowing which mutations result in disease phenotypes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate hum...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic acids research 2002-01, Vol.30 (1), p.149-151
Main Authors: Chien, Samson, Reiter, Lawrence T, Bier, Ethan, Gribskov, Michael
Format: Article
Language:English
Subjects:
Animals
Databases, Genetic
DNA Transposable Elements
Drosophila
Drosophila melanogaster - genetics
Forecasting
Genes, Insect
Genetic Diseases, Inborn - genetics
Genome
Homophila
Humans
Information Storage and Retrieval
Internet
OMIM
Sequence Homology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although many human genes have been associated with genetic diseases, knowing which mutations result in disease phenotypes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic diseases. Homophila is an intergenomic resource linking the human and fly genomes in order to stimulate functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man (OMIM) and the complete Drosophila genomic sequence. Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu.
ISSN:1362-4962
0305-1048
1362-4962
DOI:10.1093/nar/30.1.149