Efficacy of Organ Preservation Strategy by Adjuvant Chemoradiotherapy after Non-Curative Endoscopic Resection for Superficial SCC: A Multicenter Western Study

In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superfi...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2023-01, Vol.15 (3), p.590
Main Authors: Berger, Arthur, Perrod, Guillaume, Pioche, Mathieu, Barret, Maximilien, Cesbron-Métivier, Elodie, Lépilliez, Vincent, Hupé, Marianne, Perez-Cuadrado-Robles, Enrique, Cholet, Franck, Daubigny, Augustin, Texier, Charles, Ali, Einas Abou, Chabrun, Edouard, Jacques, Jérémie, Wallenhorst, Timothee, Chevaux, Jean Baptiste, Schaefer, Marion, Cellier, Christophe, Rahmi, Gabriel
Format: Article
Language:English
Subjects:
Adjuvant treatment
Cancer
Cancer therapies
Chemoradiotherapy
Comorbidity
Comparative analysis
Endoscopy
Esophageal cancer
Esophagus
Excision (Surgery)
France
Health aspects
Human health and pathology
Hydration
Hépatology and Gastroenterology
Infiltration
Life Sciences
Lymph nodes
Lymphatic system
Metastases
Metastasis
Methods
Morbidity
Mortality
Patient outcomes
Patients
Preservation
Squamous cell carcinoma
Statistical analysis
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In case of high risk of lymph node invasion after endoscopic resection (ER) of superficial esophageal squamous cell carcinoma (SCC), adjuvant chemoradiotherapy (CRT) can be an alternative to surgery. We assessed long-term clinical outcomes of adjuvant therapy by CRT after non-curative ER for superficial SCC. We performed a retrospective multicenter study. From April 1999 to April 2018, all consecutive patients who underwent ER for SCC with tumor infiltration beyond the muscularis mucosae were included. A total of 137 ER were analyzed. The overall nodal or metastatic recurrence-free survival rate at 5 years was 88% and specific recurrence-free survival rates at 5 years with and without adjuvant therapy were, respectively, 97.9% and 79.1% ( = 0.011). Independent factors for nodal and/or distal metastatic recurrence were age (HR = 1.075, = 0.031), Sm infiltration depth > 200 µm (HR = 4.129, = 0.040), and the absence of adjuvant CRT or surgery (HR = 11.322, = 0.029). In this study, adjuvant therapy is associated with a higher recurrence-free survival rate at 5 years after non-curative ER. This result suggests this approach may be considered as an alternative to surgery in selected patients.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers15030590