The Effect of Zonisamide and Ethanol on Various Types of Memory in Rats

Antiepileptic drugs might be useful in the treatment of alcohol use disorder. One of these drugs is zonisamide, which has been found to decrease alcohol intake and cravings. An important structure in the pathophysiology of addiction is the hippocampus. Memory deficits, which frequently occur in alco...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2023-01, Vol.20 (3), p.1815
Main Authors: Pietrzak, Bogusława, Krupa-Burtnik, Agata, Zwierzyńska, Ewa
Format: Article
Language:English
Subjects:
Addictions
Alcohol use
Alcoholic beverages
Alcoholics
Alcoholism
Alcohols
Animal cognition
Animals
Anticonvulsants
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Antiepileptic agents
Associative memory
Conditioning
Drug dosages
Drugs
Ethanol
Ethanol - pharmacology
Experiments
Fear
Fear conditioning
Hippocampal plasticity
Hippocampus
Memory
Memory tasks
Neurogenesis
Rats
Rats, Wistar
Spatial analysis
Spatial memory
Zonisamide
Zonisamide - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antiepileptic drugs might be useful in the treatment of alcohol use disorder. One of these drugs is zonisamide, which has been found to decrease alcohol intake and cravings. An important structure in the pathophysiology of addiction is the hippocampus. Memory deficits, which frequently occur in alcoholics, are associated with ethanol-induced changes in hippocampal plasticity and neurogenesis. The aim of this study was to assess the potential protective effect of zonisamide on memory in rats receiving alcohol and after the discontinuation of its administration. Wistar rats (n = 43) were tested in four behavioral models, namely: Morris water maze (MWM), passive avoidance (PA), contextual fear conditioning (CFC), and cued fear conditioning (CuFC). Zonisamide co-administered with ethanol impaired spatial memory in MWM, but the drug did not affect memory in PA. However, the beneficial effect of zonisamide was observed after the discontinuation of ethanol administration, which was associated with the improvement of associative memory in CFC and the alleviation of alcohol-induced locomotor disturbances in CuFC. Zonisamide has a differential influence on memory, which depends inter alia on type of the memory, length of ethanol administration, or its absence.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph20031815